博士风采

当前位置: 首页 >> 师资队伍 >> 正文

李高伟

发布时间:2017-06-24    浏览次数:


李高伟  博士  副教授,硕士生导师

联合培养单位:河南师范大学、辽宁石油化工大学

办公地址:文化路睢阳校区

Emailgoowaylee@126.com

教育经历

2014.8-2017.6,南京大学,药学,理学博士(导师:谭仁祥教授/雷新响教授)

2006.9-2009.6,郑州大学,有机化学,理学硕士(导师:王敏灿教授)

2002.9-2006.6,商丘师范学院,化学,理学学士

科研及工作经历

2009.9-至今,商丘师范学院化学化工学院,助教,讲师,副教授

2021.3-2021.7,合肥工业大学,高分子,访学,合作导师:吴宗铨教授

2018.1-2023.12,郑州大学,药学,博士后,合作导师:刘宏民教授

主讲课程

有机化学,天然药物化学,药学综合实验,有机化学实验。

教学项目及荣誉

2023年商丘师范学院课程思政样板课程《有机化学》负责人;2021年商丘师范学院教育教学改革研究项目《天然药物化学》负责人;2023年河南省第二十七届信息化交流活动高等教育微课二等奖;2022年全国大学生化学实验创新设计大赛三等奖指导教师;2023年河南省优秀学位论文(学士)指导教师

研究方向

核磁共振有机分析,高分子可控合成。

详见:https://orcid.org/0000-0003-1510-6804


代表性科研项目

[1] 高分子液晶介导的各向异性核磁共振技术的应用,河南省国际科技合作项目,2025.1-2026.1210万元

[2] 有机分子的核磁共振分析新方法与应用,河南省本科高校青年骨干教师项目(编号2024GGJS116),2024.12-2026.123万元

[3] 临床价值导向的氘代泊马度胺的研究与开发(编号232102311180),河南省科技攻关计划项目,2023.1-2024.1210万元

[4] 炎症小体特异性小分子抑制剂的设计、合成与活性研究(编号192102310143),河南省科技攻关计划项目,2019.1-2021.610万元

[5] 噻吩嵌段聚合物手性定向介质的合成及其核磁手性分析应用研究(编号21804086),国家自然科学基金青年基金)2019.1-2021.1224万元

代表性研究成果

1.

[1] Shuai-Hua Shi, Xiao-Juan Wang, Yuan-Yuan Gao, Tao Wang, Chun-Yu Wang, Zi Wang, Qiang Wang*, Fei Li*, Gao-Wei Li*. DACH-Based Chiral Sensing Platforms as Tunable Benzamide-Chiral Solvating Agents for NMR Enantioselective Discrimination. Anal. Chem., 2025, 97, 1900-1908.

[2] Yishen Wang, Haizhi Yin, Yanling Yang, Zheng-Hui Li, Gao-Wei Li*, Xinxiang Lei*. An amphiphilic peptide with unnatural amino acids as an alignment medium for RDC measurements. Magn. Reson. Lett., 2025, 5, 200171.

[3] Ming-Yang Mo, Xiao-Juan Wang, Ren-Zeng Shen, Chang-Yan Hu, Xue-Chun Li, Gao-Wei Li*, and Lan-Tao Liu*. Enantiospecific analysis of carboxylic acids using cinchona alkaloid dimers as chiral solvating agents. Anal. Chem., 2024, 96, 7487-7496.

[4] Gao-Wei Li, Xiao-Juan Wang, Shuai-Hua Shi, Lantao Liu, Jia-Qian Li, Han Sun, Zong-Quan Wu*, Xinxiang Lei*. Polyarylisocyanides derived from an alkyne-Pd(II) catalyst as robust alignment media with excellent enantiodiscimination. Anal. Chem., 2023, 95, 18850-18858.

[5] Xiao-Juan Wang, Gao-Wei Li*, Ming-Yang Mo, Shuai-Hua Shi, Si-Yu Li, Xin-Yi Liu, Lantao Liu. Synthesis of poly(3-hexylthiophene)-block-poly(phenyl isocyanide) copolymers and their self-assembly in solution. Polym. Chem., 2022, 13, 6361-6368.

[6] Xin-Jie Zhang, Run-Tan Gao, Shu-Ming Kang, Xiao-Juan Wang, Rui-Jun Jiang, Gao-Wei Li*, Li Zhou, Na Liu, Zong-Quan Wu*. Hydrogen-bonding dependent nontraditional fluorescence polyphenylallenes: Controlled synthesis and aggregation-induced emission behaviors. Polymer, 2022, 245, 124712.

[7] Gao-Wei Li, Xiao-Juan Wang, Xinxiang Lei, Na Liu*, Zong-Quan Wu*. Self-assembly of helical polymers and oligomers to create liquid crystalline alignment for anisotropic NMR parameters. Macromol. Rapid Commun., 2022, 43, 2100898. Xiao-Juan Wang, Gao-Wei Li*, Yi-Peng Cheng, Qiu-Ling Sun, Yuan-Qiang Hao*, Chen-Hong Wang, Lan-Tao Liu. Design and synthesis of dipeptidomimetic isocyanonaphthalene as enhanced-fluorescent chemodosimeter for sensing mercury ion and living cells. Front. Chem., 2022, 10, 813108.

[8] Gao-Wei Li, Xiao-Juan Wang*, Dan-Dan Cui, Yu-Fei Zhang, Rong-Yao Xu, Shuai-Hua Shi, Lan-Tao Liu*, Min-Can Wang, Hong-Min Liu, Xin-Xiang Lei*. Azaheterocyclic diphenylmethanol chiral solvating agents for the NMR chiral discrimination of alphasubstituted carboxylic acids. RSC Adv., 2020, 10, 34605-34611.

[9] Gaowei Li, Minshan Ma, Guifang Wang, Xiaojuan Wang, Xinxiang Lei*. Efficient enantiodifferentiation of carboxylic acids using BINOL-based amino alcohol as a chiral NMR solvating agent. Front. Chem., 2020, 8, 336.

[10] Gao-Wei Li, Han Liu, Feng Qiu, Xiao-Juan Wang, Xin-Xiang Lei*. Residual dipolar couplings in structure determination of natural products. Nat. Prod. Bioprospect., 2018, 8, 279-295.

[11] 李高伟,雷新响*,核磁共振残留偶极耦合参数在有机分子结构鉴定中的应用,中国科学:化学,201747(12): 1401-1423.

[12] Gao-Wei Li, Jiang-Ming Cao, Wen Zong, Li Hu, Mao-Lin Hu, Xinxiang Lei*, Han Sun*, Ren Xiang Tan*. Helical Polyisocyanopeptides as lyotropic liquid crystals for measuring residual dipolar couplings. Chem. Eur. J., 2017, 23, 7653-7656.

[13] Wen Zong#, Gao-Wei Li#, Jiang-Ming Cao, Xinxiang Lei*, Mao-Lin Hu, Han Sun*, Christian Griesinger, Ren Xiang Tan*. An alignment medium for measuring residual dipolar couplings in pure DMSO: Liquid crystals from graphene oxide grafted with polymer brushes. Angew. Chem. Int. Ed., 2016, 55, 3690-3693.

[14] Gaowei Li, Jiangming Cao, Wen Zong, Xinxiang Lei*, Renxiang Tan*. Enantiodiscrimination of carboxylic acids using the diphenylprolinol NMR chiral solvating agents. Org. Chem. Front., 2016, 3, 96-102.

[15] Shanshan Liu, Gao-Wei Li, Xiao-Chao Yang, De-Yang Zhang, Min-Can Wang*. Dinuclear zinc complex catalyzed asymmetric methylation and alkynylation of aromatic aldehydes. Org. Biomol. Chem., 2017, 15, 7147-7156.

[16] Min-Can Wang*, Gao-Wei Li, Wen-Bo Hu, Yuan-Zhao Hua, Xixi Song, Hui-Jie Lu*. A mathematical expression for the enantioselectivity and thermodynamic factors in the conformational equilibrium of catalysts in the addition of diethylzinc to benzaldehyde. Tetrahedron: Asymmetry, 2014, 25(20), 1360-1365.

[17] 李高伟,王晓娟,赵文献*,鲁刘杰,刘冠军,王敏灿*Trost氮杂半冠醚手性配体在不对称催化反应中的应用,化学进展,2012, 24(02), 348-360.

[18] 李高伟,王晓娟,赵文献*,郭保国,郑昕,王敏灿*,炔基锌与醛的催化不对称加成反应研究进展,有机化学,2010, 30(9), 1292-1304.

2.

[1] Yizhou Liu; Gary E. Martin; Gao-Wei Li; Xinxiang Lei; R. Thomas Williamson. Edited by Lishan Yao and Beat Vogeli. Residual Dipolar Couplings: Principles and Applications. Chapter 13: Anisotropic NMR Methods: Orthogonal Verification of Novel and Complex Natural Product Structures. Royal Society of Chemistry, 2024, vol.31, ch.13, pp.306-369. ISBN: 978-1-83916-429-3. Published: 16 Feb 2024. DOI: https://doi.org/10.1039/BK9781839167898-00306.

[2] 雷新响, 李高伟. “核磁共振RDC方法学研究被国家科学思想库《中国学科发展战略<手性物质化学>》学术引领专题收录, 2020, ch.6, pp.452. 国家自然科学基金委员会, 中国科学院. 北京: 科学出版社.

3. 专利

[1] 李高伟,石帅华,王晓娟,李小培,张宇恒,莫明洋,刘澜涛. 聚合物基双相溶致液晶及其制备方法和应用,中国发明专利,申请号:202410494485.8公开号:CN118373968A.

[2] 李高伟,王晓娟,陈淑敏,刘澜涛,石帅华,莫明洋,高媛媛. 胆甾端炔功能化的螺旋聚异腈高分子定向介质及其制备方法和应用,中国发明专利,申请号:202310373586.5,公开号:CN116444770A.

[3] 李高伟,王晓娟,张明亮,刘澜涛,孟团结,刘南南,程怡鹏,周广研,李新祎. 一种聚合物型溶致液晶材料及其制备方法和在手性药物拆分中的应用,中国发明专利,申请号:202010405099.9,公开号:CN111471467A,专利号:ZL 202010405099.9,授权公告日:2023-04-25.

[4] 李高伟,王晓娟,郝远强,孙秋灵,程怡鹏. 一种高选择性检测汞离子荧光探针及其合成方法与应用,中国发明专利,申请号:202010485862.3,公开号:CN111689877A,专利号:ZL 202010485862.3,授权公吿日:2022-3-25.

4. 学术报告

[1]  李高伟, 核磁共振新方法在有机分子立体化学与手性分析中的应用, 河南省化学学会2024年学术年会, 河南登封, 2025-1-102025-1-12.

[2]  李高伟, 功能性螺旋聚异腈高分子的合成、自组装及手性识别研究, 河南省化学学会2022年学术年会, 河南郑州, 2023-3-242023-3-26.

[3]  李高伟, 聚异腈高分子自组装溶致液晶用于各向异性核磁共振参数检测, 中国化学会第34届学术年会(L04:有机分析化学新发展论坛), 广东省广州市, 2024-6-156-18.